Cytoreductive nephrectomy

Kidney cancer. Principles and practice. Second edition. Primo N. Lara, Jr. Eric Jonasch (Editors). Springer International Publishing (2015)


  1. Introduction
  2. Historical perspective
  3. Randomized trials
  4. Proposed mechanisms of action
  5. Contemporary therapies
  6. Patient selection for CN
    • Predictive variables
    • Elderly
    • Non-clear cell histology
  7. Surgical Technique
    • Lymph node dissection (LND)
    • Partial nephrectomy (nephron sparing)
  8. Current controversies and future directions
  9. Conclusions
  10. References

Abbreviations

  • ccRCC — Clear cell renal cell carcinoma
  • CN — Cytoreductive nephrectomy
  • EORTC — European Organization for Research and Treatment of Cancer
  • FDA — Food and Drug Administration
  • IL-2 — Interleukin-2
  • MDACC — MD Anderson Cancer Center
  • mRCC — Metastatic renal cell carcinoma
  • MSKCC — Memorial Sloan Kettering Cancer Center
  • NCI — National Cancer Institute
  • OS — Overall survival
  • PFS — Progression-free survival RCC Renal cell carcinoma SWOG Southwest Oncology Group
  • UCLA — University of California Los Angeles

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