The role of mTOR inhibitors and PI3K pathway blockade in renal cell cancer

Kidney cancer. Principles and practice. Second edition. Primo N. Lara, Jr. Eric Jonasch (Editors). Springer International Publishing (2015)


  1. Introduction
  2. Activity of mTORC1
  3. Activity of mTORC2 and homeostatic feedback loops
  4. mTOR in RCC
  5. mTOR Inhibitors
    • Rapamycin and rapamycin analogues
  6. Mechanisms of resistance to mTOR inhibitors
  7. Conclusions
  8. References

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