Genetic predisposition to Wilms tumor | ПРЕЦИЗИОННАЯ ОНКОЛОГИЯ

Genetic predisposition to Wilms tumor

Pritchard-Jones, J.S. Dome (eds.), Renal tumors of childhood: biology and therapy. Pediatric oncology. Springer-Verlag Berlin Heidelberg (2014)

  1. Introduction
  2. Conditions with an increased risk of Wilms tumor
    • Familial Wilms tumor
    • WT1-associated syndromes
      • WAGR syndrome
      • Denys-Drash syndrome
      • Frasier syndrome
      • Non-syndromic Wilms tumor and other presentations of WT1 mutations
      • The risk of Wilms tumor with WT1 mutations
    • Overgrowth syndromes
      • 11p15-overgrowth including Beckwith-Wiedemann syndrome and hemihypertrophy
      • Perlman syndrome
      • Simpson-Golabi-Behmel syndrome
    • Other tumor predisposition syndromes
      • Fanconi anaemia types D1 and N
      • Mosaic variegated aneuploidy
      • Bloom syndrome
      • Li-Fraumeni syndrome
      • Mulibrey nanism
      • Hyperparathyroidism-jaw tumor syndrome
    • Constitutional chromosome abnormalities
      • Trisomy 18
      • Trisomy 13
      • 2q37 deletion
  1. Conditions in which Wilms tumor predisposition is unclear or uncertain
  2. Wilms tumor surveillance in predisposed individuals
  3. Future directions
    • Identification of further high-penetrance predisposition alleles
    • Clarification of Wilms tumor risks and identification of further genotype-tumor risk correlations
    • Identification of further common, low-penetrance predisposition alleles
  1. References

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