Tumor necrosis factor-α

TNF-α; is a cytokine produced by macrophages and T cells that has multiple functions in the immune response. It is the defining member of the TNF family of cytokines. These cytokines function as cell-associated or secreted proteins that interact with receptors of the tumor necrosis factor receptor (TNFR) family, which in turn communicates with the interior of the cell via components known as TRAFs (tumor necrosis factor receptor-associated factors).


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