E. Strong (ed.). Gastric cancer. Principles and practice. Springer (2015)

Although the incidence of gastric cancer has steadily declined in past decades, gastric cancer remains the second leading cause of death from cancer worldwide. There is wide variation in the incidence of gastric carcinoma across different continents, with the highest rates in Asia, central Europe, and South America. In the USA, gastric cancer is the seventh most frequent cause of cancer-related death [1]. In the past several decades, changes in clinical practice have led to the diagnosis of a higher proportion of superficial and early-stage gastric cancers, which now represents almost 20% of all newly diagnosed cancers in the USA and 50% in Japan [2–5]. The anatomic distribution of gastric cancer is also changing, with the incidence of proximal gastric tumors rising and currently representing approximately 30% of all gastric cancers [6, 7].

Epidemiologic, anatomic location, pathogenic factors, as well as molecular and genetic factors, and patterns of clinical practice all contribute to these demographic differences. This chapter intends to focus on the pathologic aspect of the disease and its implications in diagnosis and management of gastric carcinoma.

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