Kit/stem cell factor receptor in oncogenesis | ПРЕЦИЗИОННАЯ ОНКОЛОГИЯ

Kit/stem cell factor receptor in oncogenesis

Synonyms

c-Kit; Kit/SCF-R; Mast cell growth factor; MGF receptor; SCF receptor (SCF-R); Steel ligand receptor; Stem cell factor

Definition

Kit/SCF-R is a receptor protein tyrosine kinase (RPTK) encoded by the proto-oncogene c-kit, which is allelic with the murine dominant whitespotting (W) locus on chromosome 5, and whose human homolog is located on human chromosome 4 (4 q11-12).

Characteristics

Molecular and cellular regulation

Clinical relevance

Mastocytosis/mast cell leukemia

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