Principles of stem cell biology and cancer

Principles of Stem Cell Biology and Cancer, Future Applications and Therapeutics 2015 ОБЛОЖКА

Principles of stem cell biology and cancer: future applications and therapeutics. Edited by T. Regad, T. J. Sayers and R. C. Rees. John Wiley & Sons (2015)

ISBN 978-1-118-67062-0

Part I. Stem cells

Isolation and characterization of human embryonic stem cells and future applications in tissue engineering therapies »

Epigenetics, stem cell pluripotency and differentiation »

Stem cell niche and microenvironment »

Haematopoietic stem cells in therapy »

  • Introduction
  • Established clinical use of HSCs: common indications of HSCT in children
  • Emerging and experimental therapeutic uses for HSCs
  • Conclusions

Isolation and identification of neural stem progenitor cells »

  • Introduction
  • Stem cell concept
  • Neural stem cells
  • The neurosphere assay: a gold-standard assay
  • Limitations of the NSA
  • The neural colony-forming cell assay: enumeration of actual NSCs
  • Purification strategies: the quest for a cellular identity
  • Conclusions

Part II. Cancer stem cells

The role of epithelial –mesenchymal transition in cancer metastasis »

Regulation of breast CSCs by MSCs in the metastatic niche »

Isolation and identification of neural cancer stem-progenitor cells »

Colon stem cells in colorectal cancer »

Prostate cancer and prostate cancer stem cells »

  • Development and origin of the prostate
  • Adult prostate stem cells
  • Prostate cancer and prostate cancer stem cells
  • Conclusions

Stem cells and pancreatic cancer »

NANOG in cancer development »

Liver cancer stem cells and hepatocarcinogenesis »

Basic science of liver cancer stem cells and hepatocarcinogenesis »

Cancer stem cell biomarkers »

Cancer stem cells

Choice of CSC biomarkers

CSCs and breast cancer

CSCs and melanoma

CSCs and colon cancer

CSCs and brain tumours

Imperfect markers

Conclusions. References

Interactomic analysis of the stem cell marker NANOG in a prostate cancer setting »

 

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