Colon stem cells in colorectal cancer | ПРЕЦИЗИОННАЯ ОНКОЛОГИЯ

Colon stem cells in colorectal cancer

Principles of stem cell biology and cancer: future applications and therapeutics. Edited by T. Regad, T. J. Sayers and R. C. Rees. John Wiley & Sons (2015)

Part II. Cancer stem cells


Background

ISCs in the maintenance of epithelial homeostasis

Biomarkers of ISCs

DNA LRCs

CD133/prominin-1

TERT

Bmi1

Hopx

Lgr5

Lrig1

CRCSCs

CRCSC markers

CRCSC-mediated chemotherapy resistance and CRC recurrence

CRCSCs and metastasis

Heterogeneity and plasticity of CRCSCs

Regulation of CRCSCs

Stem cell signalling pathways

Other CRC signalling pathways

Tumour microenvironment

Micro-RNA

Approaches to CRCSC targeting

Conclusions

References


[contact-form-7 id=»5168″ title=»Контактная форма 1″]

0