Textbook of cell signalling in cancer | ПРЕЦИЗИОННАЯ ОНКОЛОГИЯ

Textbook of cell signalling in cancer

Textbook of Cell Signalling in Cancer_ An Educational Approach-Springer International Publishing (2015)

Русский  ⇒

Textbook of cell signalling in cancer. An educational approach. Jacques Robert. Springer International Publishing Switzerland, 2015

ISBN 978-3-319-14339-2

ISBN 978-3-319-14340-8

  1. Growth factors and tyrosine kinase receptors
  • General features of the GF–TKR interaction
    • Overview
    • Oncogenic alterations
    • Pharmacological targets
  • The paradigmatic example of the EGF (ERBB) family
    • Growth factors and their receptors
    • ERBB receptors activation
    • Oncogenic alterations
    • Pharmacological targets
  • Other families of growth factors and growth factor receptors
    • Platelet-derived growth factors and related growth factors
    • Insulin-like growth factors and their receptors
    • Fibroblastic growth factors and their receptors
    • Hepatocyte growth factor and the MET receptor
    • Glial cell line-derived neurotrophic factors and the RET receptor
    • Anaplastic lymphoma kinase and leukocyte receptor tyrosine kinase receptors
    • Vascular endothelial growth factors and their receptors
    • Angiopoietins and the TIE receptors
    • Ephrins and their receptors
    • Other growth factor: growth factor receptor couples
    • Tyrosine phosphatase receptors
  1. MAP kinase pathway
  • From receptor activation to RAS activation
  • Kinase cascade
  • Other signalling modules
  • MAP kinase substrates
    • MAP kinases-activated transcription factors
    • MAP kinase-activated kinases
  • Oncogenic alterations
  • Pharmacological targets
  1. Phosphatidylinositol 3-kinase pathway
  • From phosphatidylinositol 3-kinase to AKT proteins
  • AKT proteins and their substrates
  • mTOR protein and the TORC complexes
  • Oncogenic alterations
  • Pharmacological targets
  1. Cytokines pathway
  • Cytokines
  • Cytokine Receptors and JAK Activation
  • Signal Transduction
  • Oncogenic alterations
  • Pharmacological targets
  1. TGFβ Pathway
  • TGFβ family ligands
  • Receptors and activation
  • Signal transmission in the TGFβ pathway
  • Oncogenic alterations
  • Pharmacological targets
  1. G-Protein-coupled receptors
  • Structure and mechanism of action of G-protein-coupled receptors
    • Receptors
    • G-proteins
  • Second messengers of GPCR activation
    • Adenylyl cyclases and cyclic AMP
    • Phospholipases C, diacylglycerol and inositol 1,4,5-trisphosphate
    • RHO family small G-protein activation
    • Connections with other signalling pathways
  • Oncogenic alterations and pharmacological targets
  • Chemokine pathway
    • Chemokines and chemokine receptors
    • Chemokine signalling
    • Oncogenic alterations and pharmacological targets
  1. Wnt pathway
  • WNT ligands and their receptors
  • Wnt–β -catenin pathway
  • «Non-canonical» Wnt pathways
  • Oncogenic alterations
  • Pharmacological targets
  1. Notch pathway
    • DSL ligands
    • NOTCH receptors
    • NOTCH receptor activation and signal transmission
    • Oncogenic alterations
    • Pharmacological targets
  1. Hedgehog pathway
    • Hedgehog ligands
    • Patched receptors and their activation
    • HHG signal transduction
    • Oncogenic alterations
    • Pharmacological targets
  1. Integrins
    • Integrins and integrin ligands
      • Structural organisation of integrins
      • Integrin ligands
    • Signalling pathways arising from integrins
    • Oncogenic alterations
    • Pharmacological targets
  1. Semaphorins and adhesion molecules
  • Semaphorins and semaphorin receptors
  • Semaphorin-induced signal transmission
    • Semaphorin 3A signaling
    • Semaphorin 4D signalling
  • Oncogenic alterations and pharmacological targets
  • On some other adhesion proteins
    • Cell–cell junctions
    • Claudins
    • Cadherins
    • Selectins
    • Cell adhesion molecules of the immunoglobulin family
    • Tetraspanins
  1. Toll-like receptors, interleukin 1 and NFkB
  • IL1 family interleukins and their receptors
  • Toll-Like receptors and their ligands
  • Signal transduction from TLRs and ILRs
    • General aspects
    • NFkB pathway
    • IRF3 pathway
  • Oncogenic alterations and pharmacological targets
    • At the receptor level
    • At the NFkB level
  1. Lymphocyte receptor pathways
  • B-cell receptors
    • B-cell receptor activation
    • BCR signal transduction pathways
    • Oncogenic alterations and pharmacological targets
  • T-cell receptors
    • T-cell receptor activation
    • TCR signal transduction pathway
    • Oncogenic alterations and pharmacological targets
  1. Nuclear receptor pathways
  • Structure and function of nuclear receptors
  • Steroid hormones receptors
    • Oestrogens and progesterone receptors
    • Androgen receptors
    • Glucocorticoid receptors
  • Thyroid hormones receptors
  • Vitamin D receptors
  • Retinoic acid receptors
  • Peroxisome proliferator-activated receptors
  • Xenobiotics receptors
  1. Ion channel-coupled receptors
  • Activation of ligand-gated ion channels
  • Purinergic receptors
  • Ca2+ signalling
    • Ca2+ mobilisation signals
    • Opening of Ca2+ channels
    • Ca2+-dependent intracellular activities
    • Restoration of the initial state
    • NFAT, a transcription factor activated by Ca2+ entry
  1. Signalling by oxygen and nitric oxide
  • Hypoxia
    • Activation and role of HIF
    • Consequences of hypoxia on tumour angiogenesis
    • Consequences of hypoxia on tumour energy metabolism
    • Other consequences of hypoxia
    • Pharmacological targeting of hypoxia
  • Oxidative stress
    • Generation of reactive oxygen species
    • ROS contribution to carcinogenesis and anticancer therapy
    • ROS as signalling agents
  • Nitric oxide
    • NO• generation
    • Cell responses to NO•
    • NO• contribution to carcinogenesis and anticancer therapy
    • Guanylyl cyclase receptors
  1. Cell cycle control
  • Cell cycle phases
    • G1 Phase
    • S Phase
    • G2 Phase
    • M Phase
  • Effector proteins of cell cycle control
    • Cyclins and cyclin-dependent kinases
    • Inhibitory kinases WEE1 and MYT1
    • Phosphatases
    • Protein inhibitors of CDKs
    • Mitotic kinases
    • Checkpoint kinases and DNA integrity control kinases
    • Biochemical mechanisms of cell cycle regulation
  • Control of cell cycle progression
    • G1→S transition and DNA synthesis
    • G2→M Transition and mitosis
    • Control of DNA integrity
  • Oncogenic alterations in cell cycle control
  • Pharmacological targets
  1. Apoptosis induction and regulation
  • Proteins involved in apoptosis
    • Caspases
    • BCL2 family proteins
    • IAP family proteins
    • Death receptors and their ligands
  • Intrinsic (mitochondrial) apoptosis pathway
    • Activation of the intrinsic pathway
    • Cell death induced by the intrinsic pathway
  • Extrinsic (death receptor) apoptosis pathway
    • Activation of the extrinsic pathway
    • Cell death induced by the extrinsic pathway
    • Alternative signalling pathways induced by TNF superfamily ligands
  • Oncogenic alterations of apoptosis pathways
  • Pharmacological targets
  • Dependence receptors

A – control of DNA replication and repair

  • General organisation of the genome
  • DNA replication machinery
  • DNA repair
  • Protection of chromosomes endings

B – control of gene expression

  • Transcription machinery
  • Transcription regulation
  • DNA methylation
  • Histones and chromatin structure
  • Chromatin maintenance
  • Micro-RNAs
  • Alternative splicing
  • Control of protein activity
  • Translation machinery
  • Protein conformation and protein–protein interactions
  • Covalent post-translational protein alterations
  • Subcellular protein localisation
  • Endoplasmic reticulum stress and unfolded protein response
  • Proteolytic cleavage
  • Ubiquitinylation and proteasome
  • Sumoylation

 

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