Molecular diagnostics and tumor mutational analysis

BRAF targets in melanoma. Biological mechanisms, resistance, and drug discovery. Cancer drug discovery and development. Volume 82. Ed. Ryan J. Sullivan. Springer (2015)


  1. Introduction
  2. Somatic mutations in melanoma
    • UV damage-induced mutations
    • BRAF mutations
    • NRAS mutations
    • KIT mutations
  3. Somatic mutation testing—technology
    • Direct sequencing
    • Genomic aberrations
    • Massively parallel sequencing
    • Results of whole exome sequencing/whole genome sequencing in melanoma
  4. Conclusion
  5. References

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