Molecular diagnostics for melanoma

Molecular Diagnostics for Melanoma_ Methods and Protocols-Humana Press (2014) ОБЛОЖКА

Molecular diagnostics for melanoma: methods and protocols. Methods in molecular biology.  Magdalena Thurin and Francesco M. Marincola (eds.), vol. 1102, 2014

ISBN 978-1-62703-726-6

ISBN 978-1-62703-727-3 (eBook)

Part I. Clinical challenges and current status of treatment of melanoma »

  1. Novel insights/translational implication from the emerging biology of melanoma
  2. Emerging clinical issues in melanoma in the molecularly targeted era
  3. Integrating molecular biomarkers into current clinical management in melanoma

Part II. Biomarkers for prediction of response and resistance to treatment »

  1. Advances in adjuvant therapy: potential for prognostic and predictive biomarkers
  2. Immunologic monitoring of cancer vaccine trials using the ELISPOT assay
  3. Markers for anti-cytotoxic t-lymphocyte antigen 4 (CTLA- 4) therapy in melanoma
  4. Marker utility for combination therapy
  5. Assaying for BRAF V600E in tissue and blood in melanoma
  6. Selecting patients for KIT inhibition in melanoma
  7. Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma

Part III. Biomarkers for classification, diagnosis, and prognosis »

  1. Current status of diagnostic and prognostic markers in melanoma
  2. Chromosomal copy number analysis in melanoma diagnostics
  3. Construction and analysis of multiparameter prognostic models for melanoma outcome
  4. Immunohistochemical diagnostic and prognostic markers for melanoma
  5. Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma
  6. Tumor-infiltrating lymphocytes and their significance in melanoma prognosis
  7. Pathological staging of melanoma
  8. Genotyping of human leukocyte antigen (HLA) ancestral haplotypes as prognostic marker in cancer using PCR analysis
  9. B7-H abnormalities in melanoma and clinical relevance
  10. Melanoma susceptibility genes and risk assessment

Part IV. Uveal melanoma »

  1. Clinical, pathologic, and imaging features and biological markers of uveal melanoma
  2. A prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile
  3. Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma

Part V. Emerging markers/targets in melanoma »

  1. ERBB4 mutation analysis: emerging molecular target for melanoma treatment
  2. Epigenetic markers of prognosis in melanoma
  3. Isolation of melanoma cell subpopulations using negative selection
  4. Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients
  5. Detection of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma
  6. Targeting damage-associated molecular pattern molecules (DAMPs) and DAMP receptors in melanoma
  7. The clinical use of PET/CT in the evaluation of melanoma

Part VI. Emerging technologies for marker validation »

  1. Immune system functional pathway analysis using single cell network profiling (SCNP): a novel tool in cancer immunotherapy
  2. Quantitative and spatial image analysis of tumor and draining lymph nodes using immunohistochemistry and high-resolution multispectral imaging to predict metastasis
  3. COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing
  4. Isolation of circulating microRNAs from microvesicles found in human plasma
  5. Detection of circulating tumor cells by photoacoustic flowmetry

Part VII. Marker validation requirements for clinical applicability »

  1. Statistical design and evaluation of biomarker studies
  2. Tissue resources for clinical use and marker studies in melanoma

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