Histone deacetylase inhibitors

Oxford American handbook of oncology. Second Edition. Oxford University Press (2015)


Histone deacetylase (HDAC) is a cellular enzyme that modifies histone proteins and regulates DNA transcription, and may lead to a survival advantage in cancer cells. HDAC inhibitors block this enzyme’s activity and thus slow cancer cell growth.

Vorinostat (Zolinza)

  • Mechanism: inhibits histone deacetylase
  • Route: oral
  • Uses: cutaneous T-cell lymphoma
  • Notes: can cause fatigue, nausea, and myelosuppression. It can lead to elevated PT-INR in patients on warfarin.
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