Developing issues

Oxford American handbook of oncology. Second Edition. Oxford University Press (2015)


With the mapping of the human genome and the generation of the HapMap (a catalog of polymorphic variation), whole genome association studies have become much more feasible. These studies are rapidly identifying genetic variants that have modest, but possibly clinically meaningful, effects on cancer predisposition.

Many private companies are beginning to offer whole genome “scans” in direct marketing to consumers. At present, obtaining such information should not be encouraged for guiding any cancer evaluation outside of a research context.

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