Pathology of melanocytic disorders

Pathology of melanocytic disorders, 2nd edition. Wolter J Mooi & Thomas Krausz. Hodder Arnold, 2007


Part I. Introduction

1. Melanin, melanocytes, skin »

  • Embryology and physiology
  • Light microscopy
  • Melanin synthesis
  • Electron microscopy
  • References

2. Techniques and practical considerations »

  • Importance of clinical information and of discussion of problem cases
  • Biopsy type. clinical considerations
  • Dissection of skin biopsy specimens
  • Dissection of sentinel lymph nodes and lymphadenectomy specimens
  • Dissection of other specimens containing metastases
  • Tissue processing and staining methods
  • Morphometry
  • Other special techniques
  • Histological investigation and description
  • Referral of problem cases
  • Criteria for diagnosis. necessity and limitations
  • References

Part II. Cutaneous nevi and other pigmented skin lesions

3. Common acquired nevus »

  • Histopathology and pathogenesis of common acquired nevus; general features
  • Lentigo simplex (simple lentigo, nevoid lentigo)
  • Junctional nevus
  • Compound and intradermal nevi
  • «Activated» nevi
  • Nevi of special sites
  • Halo nevus
  • Balloon cell nevus
  • Speckled lentiginous nevus
  • Various rare nevus types
  • Recurrent nevus and nevus in blistering disorders
  • References

4. Spitz nevus and related lesions »

  • Historical note and terminology
  • Clinical features
  • General histological features
  • Recurrent Spitz nevus
  • Desmoplastic Spitz nevus
  • Pigmented spindle cell nevus (Reed nevus)
  • Other, rare Spitz nevus variants
  • Multiple Spitz nevi
  • Spitz nevus versus spitzoid melanoma; Spitz tumor of uncertain malignant potential
  • Other entities in the differential diagnosis of Spitz nevus
  • References

5. Blue nevus and related lesions »

  • Dermal melanocytoses
  • Blue nevus. general features
  • Common blue nevus
  • Cellular blue nevus
  • Deep penetrating nevus
  • Epithelioid blue nevus in Carney complex
  • Plaque-type blue nevus
  • Target blue nevus
  • Combined blue nevus
  • Compound blue nevus (Kamino nevus)
  • «Neurocristic hamartoma»
  • Paraganglioma-like dermal melanocytic tumor
  • Recurrent blue nevus
  • Involvement of regional lymph nodes
  • References

6. Congenital nevus »

  • Clinical features
  • General histological features
  • Histology in infancy and childhood
  • Histology in adolescence and adult life
  • Malignant transformation of congenital nevi
  • Special subtypes
  • Associated extracutaneous melanocytic lesions
  • References

7. Malignant transformation of nevi; dysplastic nevi »

  • Nevi and melanoma risk
  • Dysplastic nevus and dysplastic nevus syndrome
  • Dysplastic nevus. terminology, and microscopic and histological features
  • Dysplastic nevus versus other nevi
  • Dysplastic nevus. separate entity or integral part of the spectrum of nevi?
  • Dysplastic nevus versus (small and thin) melanoma
  • Dysplastic nevi in contiguity with melanoma, and concluding remarks
  • References

8. Cutaneous pigmented lesions not related to melanocytic nevi or melanoma »

  • Generalized and regional hyperpigmentation
  • Ephelis (freckle)
  • Solar lentigo (sentile lentigo; «liver spot»)
  • Cafe-au-lait spot
  • Becker nevus (pigmented hairy epidermal nevus)
  • Xeroderma pigmentosum
  • Hyperpigmentation of cutaneous scars
  • Melanotic macule of the nail
  • PEComa of the skin
  • Reactive pigmentation and melanocyte colonization of skin tumors
  • Cutaneous pigmented tumors derived from the peripheral nervous system
  • Melanotic fungal infections
  • References

Part III. Cutaneous melanoma

9. Melanoma general features »

  • Incidence, death rates
  • Risk factors
  • Pathogenesis
  • Age and sex distribution, anatomical sites
  • Multiple melanoma
  • Macroscopic appearance, clinical approach
  • Histological diagnosis. general remarks
  • Architecture of primary melanoma
  • Cytological features of melanoma
  • Primary versus metastatic melanoma
  • References

10. Melanoma subtypes and variants »

  • Some problems associated with melanoma subtyping
  • Superficial spreading melanoma
  • Nodular melanoma
  • Lentigo maligna and lentigo maligna melanoma
  • Acral melanoma
  • Desmoplastic and neurotropic melanoma
  • Nevoid melanoma
  • Primary dermal melanoma
  • Various rare melanoma variants
  • Melanoma arising in congenital nevus
  • Metastatic melanoma simulating other neoplasms
  • Immunohistological diagnosis of melanoma
  • Ultrastructure of metastatic melanoma
  • References

11. Cytological diagnosis of melanoma »

  • Methods
  • Microscopic features. general remarks
  • Epithelioid cell melanoma
  • Spindle cell melanoma
  • Melanomas of mixed cell type
  • Uveal melanomas
  • Cytological features of melanoma in ThinPrepR specimens and in specimens other than fine needle aspiration
  • References

12. Melanoma prognosis and staging »

  • Site, sex, age
  • The American Joint Committee on Cancer staging system for cutaneous melanoma
  • Melanoma subtypes
  • Thin melanoma
  • Inflammatory response, regression
  • Vasculogenesis, vascular invasion
  • Mitotic rate
  • Various other features
  • Local melanoma recurrence
  • Late melanoma recurrence
  • Metastatic melanoma with unknown primary
  • References

Part IV. Extracutaneous melanotic tumors

13. Extracutaneous melanocytic tumors »

  • Melanocytic lesions of mucous membranes. general considerations
  • Melanocytic lesions not associated with mucous membranes. general considerations
  • Central nervous system
  • Eye and orbital cavity
  • Nasal cavity and paranasal sinuses
  • Labial mucosa, oral cavity, and oropharynx
  • Parotid gland
  • Larynx and esophagus
  • Lower respiratory tract
  • Thymus
  • Intestines
  • Genitourinary tract
  • Lymph node
  • Adrenal gland
  • References

14. Other extracutaneous melanotic tumors »

  • Central nervous system
  • Peripheral nervous system
  • Eye
  • The head and neck region
  • Digestive tract
  • Genital tract
  • Breast
  • Clear cell sarcoma of soft tissues
  • Perivascular epithelioid cell tumors
  • Peritoneum
  • Endocrine tissues
  • Lymph nodes
  • Miscellaneous lesions
  • References

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