Oxford American handbook of oncology. Second Edition. Oxford University Press (2015)
- Alteration in a preexisting pigmented mole on the skin
- Anew pigmented lesion: This is particularly relevant if the patient is .40 years old, when the acquisition of new moles is uncommon.
- Irregular brown or black pigmentation of a lesion.
- Irregular border or new asymmetry of a lesion
- Oozing, crusting, itching, or bleeding
- Differential diagnosis: (1) benign melanocytic nevi; (2) seborrheic keratoses (older ages).
- Palpable regional lymphadenopathy
- Metastatic disease to viscera (primary lesion may not be identified)