Clinical presentation

Oxford American handbook of oncology. Second Edition. Oxford University Press (2015)


  • Alteration in a preexisting pigmented mole on the skin
  • Anew pigmented lesion: This is particularly relevant if the patient is .40 years old, when the acquisition of new moles is uncommon.
  • Irregular brown or black pigmentation of a lesion.
  • Irregular border or new asymmetry of a lesion
  • Oozing, crusting, itching, or bleeding
  • Differential diagnosis: (1) benign melanocytic nevi; (2) seborrheic keratoses (older ages).

Less common

  • Palpable regional lymphadenopathy
  • Metastatic disease to viscera (primary lesion may not be identified)

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