Textbook of cell signalling in cancer

Textbook of cell signalling in cancer. An educational approach. Jacques Robert. Springer International Publishing Switzerland, 2015


Introduction: general principles of cell signalling from receptors to effectors cell signalling and cancer .

Growth factors and tyrosine kinase receptors »

  1. General features of the GF–TKR interaction
    • Overview
    • Oncogenic alterations
    • Pharmacological targets
  2. The paradigmatic example of the EGF (ERBB) family
    • Growth factors and their receptors
    • ERBB receptors activation
    • Oncogenic alterations
    • Pharmacological targets
  3. Other families of growth factors and growth factor receptors
    • Platelet-derived growth factors and related growth factors
    • Insulin-like growth factors and their receptors
    • Fibroblastic growth factors and their receptors
    • Hepatocyte growth factor and the MET receptor
    • Glial cell line-derived neurotrophic factors and the RET receptor
    • Anaplastic lymphoma kinase and leukocyte receptor tyrosine kinase receptors
    • Vascular endothelial growth factors and their receptors
    • Angiopoietins and the TIE receptors
    • Ephrins and their receptors
    • Other growth factor: growth factor receptor couples
  4. Tyrosine phosphatase receptors

MAP kinase pathway »

  1. From receptor activation to RAS activation
  2. Kinase cascade
  3. Other signalling modules
  4. MAP kinase substrates
    • MAP kinases-activated transcription factors
    • MAP kinase-activated kinases
  5. Oncogenic alterations
  6. Pharmacological targets

Phosphatidylinositol 3-kinase pathway »

  1. From phosphatidylinositol 3-kinase to AKT proteins
  2. AKT proteins and their substrates
  3. mTOR protein and the TORC complexes
  4. Oncogenic alterations
  5. Pharmacological targets

Cytokines pathway »

  1. Cytokines
  2. Cytokine Receptors and JAK Activation
  3. Signal Transduction
  4. Oncogenic alterations
  5. Pharmacological targets

TGFβ Pathway »

  1. TGFβ family ligands
  2. Receptors and activation
  3. Signal transmission in the TGFβ pathway
  4. Oncogenic alterations
  5. Pharmacological targets

G-Protein-coupled receptors »

  1. Structure and mechanism of action of G-protein-coupled receptors
    • Receptors
    • G-proteins
  2. Second messengers of GPCR activation
    • Adenylyl cyclases and cyclic AMP
    • Phospholipases C, diacylglycerol and inositol 1,4,5-trisphosphate
    • RHO family small G-protein activation
    • Connections with other signalling pathways
  3. Oncogenic alterations and pharmacological targets
  4. Chemokine pathway
    • Chemokines and chemokine receptors
    • Chemokine signalling
    • Oncogenic alterations and pharmacological targets

Wnt pathway »

  1. WNT ligands and their receptors
  2. Wnt–β -catenin pathway
  3. ‘Non-canonical’ Wnt pathways
  4. Oncogenic alterations
  5. Pharmacological targets

Notch pathway »

  1. DSL ligands
  2. NOTCH receptors
  3. NOTCH receptor activation and signal transmission
  4. Oncogenic alterations
  5. Pharmacological targets

Hedgehog pathway »

  1. Hedgehog ligands
  2. Patched receptors and their activation
  3. HHG signal transduction
  4. Oncogenic alterations
  5. Pharmacological targets

Integrins »

  1. Integrins and integrin ligands
    • Structural organisation of integrins
    • Integrin ligands
  2. Signalling pathways arising from integrins
  3. Oncogenic alterations
  4. Pharmacological targets

Semaphorins and adhesion molecules »

  1. Semaphorins and semaphorin receptors
  2. Semaphorin-induced signal transmission
    • Semaphorin 3A signaling
    • Semaphorin 4D signalling
  3. Oncogenic alterations and pharmacological targets
  4. On some other adhesion proteins
    • Cell–cell junctions
    • Claudins
    • Cadherins
    • Selectins
    • Cell adhesion molecules of the immunoglobulin family
    • Tetraspanins

Toll-like receptors, interleukin 1 and NFkB »

  1. IL1 family interleukins and their receptors
  2. Toll-Like receptors and their ligands
  3. Signal transduction from TLRs and ILRs
    • General aspects
    • NFkB pathway
    • IRF3 pathway
  4. Oncogenic alterations and pharmacological targets
    • At the receptor level
    • At the NFkB level

Lymphocyte receptor pathways »

  1. B-cell receptors
    • B-cell receptor activation
    • BCR signal transduction pathways
    • Oncogenic alterations and pharmacological targets
  2. T-cell receptors
    • T-cell receptor activation
    • TCR signal transduction pathway
    • Oncogenic alterations and pharmacological targets

Nuclear receptor pathways »

  1. Structure and function of nuclear receptors
  2. Steroid hormones receptors
    • Oestrogens and progesterone receptors
    • Androgen receptors
    • Glucocorticoid receptors
  3. Thyroid hormones receptors
  4. Vitamin D receptors
  5. Retinoic acid receptors
  6. Peroxisome proliferator-activated receptors
  7. Xenobiotics receptors

Ion channel-coupled receptors »

  1. Activation of ligand-gated ion channels
  2. Purinergic receptors
  3. Ca2+ signalling
    • Ca2+ mobilisation signals
    • Opening of Ca2+ channels
    • Ca2+-dependent intracellular activities
    • Restoration of the initial state
    • NFAT, a transcription factor activated by Ca2+ entry

Signalling by oxygen and nitric oxide »

  1. Hypoxia
    • Activation and role of HIF
    • Consequences of hypoxia on tumour angiogenesis
    • Consequences of hypoxia on tumour energy metabolism
    • Other consequences of hypoxia
    • Pharmacological targeting of hypoxia
  2. Oxidative stress
    • Generation of reactive oxygen species
    • ROS contribution to carcinogenesis and anticancer therapy
    • ROS as signalling agents
  3. Nitric oxide
    • NO• generation
    • Cell responses to NO•
    • NO• contribution to carcinogenesis and anticancer therapy
  4. Guanylyl cyclase receptors

Cell cycle control »

  1. Cell cycle phases
    • G1 Phase
    • S Phase
    • G2 Phase
    • M Phase
  2. Effector proteins of cell cycle control
    • Cyclins and cyclin-dependent kinases
    • Inhibitory kinases WEE1 and MYT1
    • Phosphatases
    • Protein inhibitors of CDKs
    • Mitotic kinases
    • Checkpoint kinases and DNA integrity control kinases
    • Biochemical mechanisms of cell cycle regulation
  3. Control of cell cycle progression
    • G1→S transition and DNA synthesis
    • G2→M Transition and mitosis
    • Control of DNA integrity
  4. Oncogenic alterations in cell cycle control
  5. Pharmacological targets

Apoptosis induction and regulation »

  1. Proteins involved in apoptosis
    • Caspases
    • BCL2 family proteins
    • IAP family proteins
    • Death receptors and their ligands
  2. Intrinsic (mitochondrial) apoptosis pathway
    • Activation of the intrinsic pathway
    • Cell death induced by the intrinsic pathway
  3. Extrinsic (death receptor) apoptosis pathway
    • Activation of the extrinsic pathway
    • Cell death induced by the extrinsic pathway
    • Alternative signalling pathways induced by TNF superfamily ligands
  4. Oncogenic alterations of apoptosis pathways
  5. Pharmacological targets
  6. Dependence receptors

 

A – control of DNA replication and repair »

  • General organisation of the genome
  • DNA replication machinery
  • DNA repair
  • Protection of chromosomes endings

B – control of gene expression »

  • Transcription machinery
  • Transcription regulation
  • DNA methylation
  • Histones and chromatin structure
  • Chromatin maintenance
  • Micro-RNAs
  • Alternative splicing

C – control of protein activity »

  • Translation machinery
  • Protein conformation and protein–protein interactions
  • Covalent post-translational protein alterations
  • Subcellular protein localisation
  • Endoplasmic reticulum stress and unfolded protein response
  • Proteolytic cleavage
  • Ubiquitinylation and proteasome
  • Sumoylation

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