Introduction

BRAF targets in melanoma. Biological mechanisms, resistance, and drug discovery. Cancer drug discovery and development. Volume 82. Ed. Ryan J. Sullivan. Springer (2015)


Ethical issues have been a focus of controversy since the advent of clinical research in humans. More recently, much has been written about the ethics of clinical trials in oncology. The past few years have borne witness to much debate over key aspects of randomized study design involving targeted therapies for advanced melanoma; equipoise, randomization, crossover, and early stopping rules. In this chapter, we will summarize the key ethical issues in clinical research, with a focus on the topics relevant to randomized clinical trials of novel therapies for melanoma.

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